Factors affecting colonic motility: Response to a standard meal in patients with total gastrectomy, pernicious anemia or duodenal ulcer

Abstract

An increase in pressure activity in the colon after food is ingested may be responsible for colonic pain in some cases (1, 2). We have therefore "measured the motor response of the colon to a standard meal in patients with total gastrectomy, pernicious anemia or duodenal ulcer. These groups were selected because they differ widely with respect to the integrity of the vagus nerve, gastric acid output, circulating gastrin and entry rate of food into the Upper small intestine. This work is described in detail elsewhere (3). Pressure changes in the proximal colon were measured by radiotelemetering capsules and in the distal colon by miniature balloons connected to pressure transducers. Transit was detected by radiopaque pellets. Meals were of standard protein, carbohydrate, fat and water content. Pressure activity increased during and after the meal in the proximal colon, sigmoid colon and rectum of all 3 groups of patients, and this response was detectable within a few minutes of starting to eat. In tile sigmoid colon, the response was greater

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